Google might open retail stores specifically for Google Glass

On the southern edge of Louisiana, there is almost as much water as land. You can't drive to anyone's house, you have to travel by boat, and sometimes there are hours of water between neighbors. It takes a special breed to make a home here, in the swamp, amongst the mosquitos and almost annual hurricanes. But those who do call it home, love it. They see a magical space of strange stillness and subtle rippling greens and grays where time worries no one and the freedom of the water is at your doorstep.?

Source: http://news.yahoo.com/google-might-open-retail-stores-specifically-google-glass-205543391.html

westboro baptist church meteor shower NBA Al Michaels Canelo vs Trout 420 Meteor Showers 2013

Mathematicians help to unlock brain function

Monday, May 6, 2013

Mathematicians from Queen Mary, University of London will bring researchers one-step closer to understanding how the structure of the brain relates to its function in two recently published studies.

Publishing in Physical Review Letters the researchers from the Complex Networks group at Queen Mary's School of Mathematics describe how different areas in the brain can have an association despite a lack of direct interaction.

The team, in collaboration with researchers in Barcelona, Pamplona and Paris, combined two different human brain networks - one that maps all the physical connections among brain areas known as the backbone network, and another that reports the activity of different regions as blood flow changes, known as the functional network. They showed that the presence of symmetrical neurons within the backbone network might be responsible for the synchronised activity of physically distant brain regions.

Lead author Vincenzo Nicosia, said "We don't fully understand how the human brain works. So far the focus has been more on the analysis of the function of single, localised regions. However, there isn't a complete model that brings the whole functionality of the brain together. Hopefully, our research will help neuroscientists to develop a more accurate map of the brain and investigate its functioning beyond single areas."

The research adds to the recent findings published in Proceedings of the National Academy of Sciences in which the QM researchers along with the Department of Psychiatry at University of Cambridge analysed the development of the brain of a small worm called Caenorhabditis elegans. In this paper, the team examined the number of links formed in the brain during the worm's lifespan, and observed an unexpected abrupt change in the pattern of growth, corresponding with the time of egg hatching.

"The research is important as it's the first time that a sharp transition in the growth of a neural network has ever been observed," added Dr Nicosia.

"Although we don't know which biological factors are responsible for the change in the growth pattern, we were able to reproduce the pattern using a simple economical model of synaptic formation. This result can pave the way to a deeper understanding of how neural networks grow in more complex organisms."

The Complex Networks group at Queen Mary is headed by Professor Vito Latora. Aside from theoretical research about the structure and function of complex networks, the group is working on the characterisation of multi-layer brain networks, aimed at reconciling and integrating different brain signals to produce a more informative picture of the human brain.

###

Queen Mary, University of London: http://www.qmul.ac.uk

Thanks to Queen Mary, University of London for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 51 time(s).

Source: http://www.labspaces.net/128129/Mathematicians_help_to_unlock_brain_function

jodie foster seahawks natalie wood patriots Sandy Hook Hoax 2014 Corvette Stacie Halas

Online Web Marketing: Three Internet Business Tips

Online Web marketing should be approached with the same frame of mind you would undertake any commercial enterprise. A lot of Internet business tips can apply to any kind of business, however there are some that need more attention as you are running your own business. This means you need to organize and prioritize your work yourself to get the most productive results. Steering clear of distractions and concentrating on the task at hand can be hard.

Organize Your Tasks

Plan your work each day so most of your time is spent on activities that are building your business. You will decide on what works best for you but I am a list person. For me, it is simple and effective. I write a list of the jobs I want to do that day according to their importance. Those I do not get done that day, go to the top of the list the next day. Each night, when I review the work for the day, I make a list for the next day.

Sort the Urgent and Important Tasks

You can refine your list by sorting it into the urgent and the important. It is easy to be put off course by something that seems to require your urgent attention. It is natural to respond to this and to want to deal with it immediately. The real danger is you can jump at the chance to deal with it because you can use it as an excuse to avoid the important, but much harder, job you had planned ? and you were not really looking foreword to tackling it. Be aware of that, and make yourself knuckle down to the job at hand.

If you do have some urgent tasks that will not take much time, but are going stress and sidetrack you, get them done and out of the way. But, generally speaking, it is a lot better to put aside a time every day to attend to those necessary but less important jobs. This can be the same time every day.

Give Your Tasks a Time Frame

You will be more productive if you give your tasks a time frame. You do not have to become a slave to an exact timetable. Simply make a reasonable estimate of the time you will need to do a particular job. This will help you set some deadlines and plan your work. You will be able to gauge what work you can expect to complete in the time available. This can help you avoid setting unrealistic targets and then feeling stressed when you don?t meet them. One of the benefits of planning is to make life easier and you won?t do this by putting more pressure on yourself.

These are not just Internet business tips but can be applied to any business. Whether you are doing online Web marketing full or part-time, you are responsible for your own work time and you need to make it productive. You have to pay particular attention to this if you are working from home, as there are usually more distractions than in an office environment.

.

Tagged as: achieve objectives, internet business, internet business tips, internet marketer, internet marketing, online Web marketing, set goals, set priorities, set time frame, stay motivated

Source: http://liveamericandreamnow.com/?p=7278

cabin in the woods the legend of korra three stooges the three stooges the bee gees woodward keratosis pilaris

James wins MVP, 1 vote shy of unanimously

MIAMI (AP) ? LeBron James was at his best this season, and the voters tasked with selecting the NBA's Most Valuable Player took notice.

Every voter except one, that is.

The NBA still does not have a unanimous MVP, though no one has come closer than James did this season. The Miami Heat star was presented with the Maurice Podoloff Trophy for the fourth time in his career on Sunday after collecting 120 of the 121 first-place votes, with Carmelo Anthony of the New York Knicks picking up the lone remaining top choice.

"It was probably a writer out of New York that didn't give me that vote," James said. "And we know the history between the Heat and the Knicks, so I get it."

A panel of 120 sports writers and broadcasters cast ballots in the NBA MVP voting, with a combined online fan vote also being taken into account.

Shaquille O'Neal got every first-place vote but one in the 1999-2000 season, when one person cast his ballot for Allen Iverson ? who finished seventh that year. This season, Kevin Durant of the Oklahoma City Thunder finished second, well ahead of Anthony, who was third and didn't even appear on nine of the ballots cast. James was the only player listed on all 121 ballots; Durant was omitted from two, according to the results released by the NBA.

"I'll take that vote," Anthony said, adding that James was a deserving winner.

For months, there really had only been two questions about this season's MVP race: When will James get the award, and would the results be unanimous? The first of those answers became known Friday, the other on Sunday, and even as he was on the dais to pick up the award the now-four-time MVP quickly started steering all of his attention back to the goal of helping the Heat win a second straight title.

Miami hosts Chicago in Game 1 of the Eastern Conference semifinals on Monday night, when NBA Commissioner David Stern will present James with the trophy, largely just for the benefit of giving Heat fans a pregame reason to cheer.

"My ultimate goal is to win an NBA championship," James said. "That's what I was brought here for. That's why I signed here as a free agent in 2010. It wasn't to win MVP trophies. It was to win a championship ? and win multiple championships ? and that's still my No. 1 priority."

James averaged 26.8 points, 8.0 rebounds and 7.3 assists this season, leading Miami to a league-best 66-16 record while shooting a career-high 56 percent. Only Kareem Abdul-Jabbar (six), Michael Jordan (five), Bill Russell (five) and Wilt Chamberlain (four) have as many MVP awards, only Russell won four in a five-year span, and only Abdul-Jabbar went back-to-back twice, like James did with trophies in 2009 and 2010 and now again in 2012 and 2013.

Sunday's ceremony was filled with tributes and even some laughs, like when James' younger son Bryce posed for photographers on stage while his father was speaking and older brother LeBron Jr. looked on ? and when James' fiancee, Savannah Brinson, appeared on a congratulatory video and called him "Honeybunny."

"I know you're embarrassed when I call you that," Brinson said. "But whatever."

Over on the far side of the dais, set up on the floor of the Heat home court, James' teammates roared in hysterics ? and Udonis Haslem made sure James knew that they were talking about Brinson's pet name for her future husband. The 14 other Heat players were dressed casually in team garb, while James donned a dapper suit for the festivities.

As he did on Saturday, a day after it became widely known that the award would be his again, James thanked his teammates.

"I'd rather be sitting over there in shorts and a T-shirt, wondering what the hell they're joking about, because I want to be a part of that joke," James said. "And I hate being out of all the jokes. I want to know what was happening, OK, guys? I would much rather be with my guys over there because that's what it's all about. Without those guys, this trophy is not possible."

Much of the ceremony was tinged with emotion.

Brinson's mother dabbed tears away from her eyes when James thanked his soon-to-be in-laws for what they do for his family. Dwyane Wade (who was 10th in the voting) spoke in a hushed tone on the video, with soft music playing in the background as he told James to "continue to lead this team because we believe in you, so congratulations, Mr. MVP." James seemed genuinely touched when dozens of students who are part of his "I Promise" educational program chanted for him when the proceedings were complete.

"And all the ones that I've observed and I've watched and I've seen, somewhere they've always gotten better," said Heat President Pat Riley, talking about all the game's stars that he's witnessed in his 46 NBA years. "They always got better as their career advanced. And most importantly, they've always made their teammates and their team better. In my humble opinion ... I think the man that we're looking at right here is the best of all of them."

James was the only player in the NBA to lead his team in scoring, rebounding and assists per game this season, had a record six straight games of scoring at least 30 points while shooting at least 60 percent, became the youngest player in league history to break the 20,000-career-point plateau and won five of the six Eastern Conference player of the month awards.

James is now the second player in NBA history to post at least 2,000 points, 600 rebounds, 500 assists and 100 steals in a season twice, joining Larry Bird, who did it three times. The only other player to do it once was Jordan.

"Four now," Heat managing general partner Micky Arison said. "And more to come."

Source: http://news.yahoo.com/james-wins-mvp-1-vote-shy-unanimously-190623555.html

666 Park Avenue Kara Alongi Sahara Davenport Resident Evil 6 arnold schwarzenegger revenge revenge

AP PHOTOS: Few know story of Jews in Red Army

JERUSALEM (AP) ? Once a year, Israel's Jewish war veterans don suit jackets and uniforms dripping in Red Army medals, the shiny bronzes and silvers pinned to their chests in tight rows like armor.

About 500,000 Jews served in the Soviet Red Army during World War II. Most of those still alive today ? about 7,000 ? are said to live in Israel.

Every year on Victory Day, which falls on Thursday this year, they parade in uniform throughout Israel to celebrate Nazi Germany's surrender to the Soviet Union.

Afterward, they return home to their modest apartments, where some tick off the days in solitude ? and poverty.

"The ceremonies are beautiful. People like to come and say nice words. But nice words don't put food on your plate," said Abraham Michael Grinzaid, 87, head of an association of Soviet war veterans. "The rest of the year, no one thinks of us."

About 1.5 million Jews fought in Allied armies, including 500,000 in the Red Army, 550,000 in the American army, 100,000 in the Polish army and 30,000 in the British army, according to Israel's Holocaust museum Yad Vashem.

Some of those who fought in the Red Army served in the highest levels of command. About 200,000 Soviet Jewish soldiers fell on the battlefield or into German captivity. Those who survived built families and careers in the Soviet Union, until the Communist regime collapsed and many of them ended up in Israel.

They formed a veterans' association, opening 50 chapters across the country. Today, most of them are nearly 90 years old, but they gather regularly for lectures and concerts. Some sing in the 42 veterans' choirs nationwide.

Israel is home to the world's largest population of Holocaust survivors. Memorials to Holocaust victims and underground partisans are aplenty. But only in recent years has the Jewish state begun to salute its Jewish war veterans.

That's mostly because many of the veterans immigrated just two decades ago and key war archives are only now being opened, allowing researchers to discover the full extent of Jewish soldiers' role in fighting the Nazis, said Red Army scholar Yitzhak Arad.

It wasn't until last year that Israel erected its first monument to Soviet Jewish soldiers who served in WW II. A museum dedicated to Jewish Allied fighters is still under construction.

Grinzaid, of the veterans association, complained that some Soviet war veterans in Israel receive government stipends amounting to just $50 a month, a pittance compared to the financial support Israeli Holocaust survivors receive.

But Roman Yagel, the head of another group of Soviet veterans, countered that veterans receive generous Israeli support. He accused Grinzaid of securing stipends for undeserving veterans who did not fight on the battlefield with weapons in hand ? one example of bitter political infighting within the Soviet veteran community.

Holocaust survivors are frequently invited to speak about the horrors they experienced. But Soviet war veterans arrived in Israel as pensioners and most never learned Hebrew so few Israelis know their stories.

Grinzaid was 17 ? when he enlisted in the Red Army. He was a paratrooper and served in an intelligence unit, earning five medals for his participation in battles across Europe. When Russian President Vladimir Putin came to Israel last year, he shook his hand.

Another Soviet veteran, Matvey Gershman, 87, helped liberate the Majdanek concentration camp in Poland. He remembers walking past storerooms filled with women's hair and children's shoes.

Suddenly, he stumbled upon a woman sitting and crying.

"I said, 'Grandmother, why are you crying? It's all over,'" Gershman recalled. "She lifted her head, looked at me, and said, 'I am 20 years old.'"

Gersham used to march in Israel's annual Victory Day parade before he had heart problems.

One year, he walked to the parade with his daughter and grandson, wearing his navy blue uniform featuring a cascade of medallions. Israeli teenagers on the street pointed at him and laughed.

"They treated him like he was a clown," said his daughter, Rimma. "He doesn't want to go out with these medals on anymore. He's embarrassed. They don't know what it is at all."

Source: http://news.yahoo.com/ap-photos-few-know-story-jews-red-army-130323021.html

dan marino godaddy did the groundhog see his shadow Ray Lewis Murder UFC 156 my bloody valentine Super Bowl Winners

BIMBuilder.com / Revit 3D: Autodesk - Legal Notices & Trademarks ...

Updated:? March 19, 2013 We have updated our Privacy Statement to make it easier to read, and to include our privacy practices for our personal design and creativity tools such as Socialcam, Instructables, Pixlr and imm.io.? We continue to treat your personal information with care and respect.

What this privacy statement covers
This privacy statement tells you about our privacy practices for our websites, products, online and web services, and apps that include a link or reference to this statement.?It also tells you about our marketing and advertising practices, and applies to our offline practices.?In this statement we will refer to our products, online and web services and apps as "applications."?

Some of our websites and applications may display supplemental privacy or data collection notices that we share so you can make informed choices about what you want to do when you review the notices.?For example, you may see a notice explaining data collection practices for an application, and your choices for participating.?In special cases, websites and applications may have their own privacy policies.?For example, we may buy another company to expand our business, and need some time to integrate the company's privacy practices with ours.

Third parties (such as social media platforms or other company websites that we link to from our websites and applications) are responsible for their own privacy practices.?Be sure to read the privacy policies, supplemental notices, and settings of all websites or platforms that you visit so you can understand their privacy practices and your options.

Some websites and applications are subject to additional terms such as our website?terms of use,?terms of service, and?software license agreements.?Please read the terms that apply to the website or application you are using.?These terms can help answer questions you may have about the confidentiality and security of designs and other content you create, and the effect of sharing and posting of content by you. How to contact
If you have questions, concerns or complaints you can contact us through our?webform, by e-mail at?privacy.questions@autodesk.com, or by postal mail to the address below:

Privacy Questions
Autodesk, Inc.
The Landmark @ One Market
Suite 500
San Francisco, CA 94105
U.S.A.

Information we collect about you

User IDs, registration, and contact
We collect information that identifies you when you

• register to use one of our websites or applications
• register to attend an event
• create a user ID to access our websites or applications
• contact us for services, support, information or other reasons

We may collect your name, company name, email address and other contact information, a profile image (which may be a picture of you), or payment information.? Sometimes we collect other information that does not identify you, like your job title, industry or interests.? Some information is required, and other information is optional.?

For student and education versions of our applications, we may require information to confirm your eligibility.? For our customers who make purchases through our channel partners or ecommerce providers, we will receive personal information about you from these companies so that we can have an accurate record of applications to which you have access.?

To help keep our databases current and to provide you with more relevant content, experiences and offerings, we may combine information you give us with information from public sources and trustworthy companies (such as our resellers and ecommerce providers, and business contact databases), all in accordance with applicable law.?

For example, these sources can tell us about the company size and industry of our business customers, and also help us maintain the accuracy of our databases.

Autodesk desktop product activation and automatic updates
When you activate an Autodesk desktop application, we collect information about your system, the desktop application you are activating, and the application (product) serial number.?Learn more about activation. Some of our applications include features that connect to our servers and let you install updates to the application. We may keep track of information such as whether the update was successful or not.

Websites and applications
Our websites or applications may collect usage information so we can manage our agreement with you or the company, organization or institution through which you receive access ? for example, so we know how much to charge based on amount of use, or when the limit of the services paid for has been reached.?You can get more information by reading the terms of service or software license agreement that applies to the applications you are using, and by talking to your license or contract administrator.

Some of our websites and applications include specific data collection programs.?Depending on the website or application, this information may or may not be associated with your personal information.?You can learn more about?specific programs, as well as?your choices?about how we use this information.

Automatic data collection tools, cookies and similar technologiesWhen you communicate with us, access our websites and applications through a browser, application, or other client, our servers automatically collect and record certain information.?For example, your browser or device may tell us your browser type, language preference and the Internet Protocol (IP) address (which may tell us generally where you are located) and the type of device or system you used. Your browser may also tell us information such as the time and date of your request, page that led you to our website and, if applicable, the search terms you typed into a search engine that led you to our website.

When we send you emails, they might include a web beacon or similar technology that lets us know if you received or opened the email and whether you clicked on any of the links in the email.?You can?opt-out of marketing emails.

Buttons, tools, ads, and content from other companiesOur websites and applications may include buttons, tools, advertisements, or content that links to another companies' services (for example, a Facebook "Like" button on a webpage, a Google Maps feature in an application, or an ad in a mobile app). We may collect information about your use of these features.

In addition, when you see or interact with these buttons, tools, ads, or content, or view our webpage or application containing them, some information from your browser may automatically be sent to the other company. Please read that company's privacy policy for more information.?You can also learn more about?application usage metrics,cookies?and your?advertising choices. Advertising
Our websites and applications may feature ads for other companies' products and services, as well as for ads our own applications.

We may work with one or more advertising networks (each an Ad Partner) who use cookies, tracking pixels, or other technologies to collect information in order to serve you ads and help us track results.?Examples of this information may include, but are not limited to, websites you visit, mobile apps you use, preferences you may provide us as the app provider (such as language preferences), your IP address (for purposes of determining your general location), device ID, MAC address, and browser information.?This information helps:

• ensure that appropriate advertising is shown in the application or on the website
• calculate and control the number of unique and repeat views of a given ad
• deliver ads that relate to your interests, and
• measure the effectiveness of ad campaigns

Some technology enables advertising to be temporarily uploaded onto your mobile device and replaced while you are online.

We do not actively share personal information with our Ad Partners or third party advertisers for their direct marketing purposes unless you give us your consent.?Our Ad Partners deliver ads for us and may combine the information collected or obtained from us with other information they have independently collected from other websites and/or other online or mobile products and services relating to your browser's activities across their network of websites.

Please note that if you choose to click on an ad or participate in promotions of any third-party advertisers via an ad that appears in our application, this is solely between you and the advertiser and your participation is subject to the terms and conditions associated with that ad or promotion.

Social sign on and social networking
Some of our websites and applications may allow you to sign in using a social networking platform account (such as Facebook, Google+ or Twitter).?Social sign-on features may make creating an account with us faster for you by pre-populating our registration or user profile form with information you provided to the social networking platform. The first time you use a social sign-on service, the social media platform typically explains what information will be shared with us.

Also, we have pages on many social networking platforms where you can visit and communicate with us.?We may collect information when you visit our social networking pages.?We will use this and social sign-on information for the purposes described in this privacy statement.?Be sure to review the privacy and data usage policies of any social networking platform you use to learn more about its personal information practices and your options.

ChildrenSome Autodesk websites and applications are intended for general audiences.?However, we do not knowingly collect any personal information from children aged 12 years old and under. In some jurisdictions, notification, prior written permission or other verifiable parental consent may be required of a parent or guardian for children from 13 to 17 years of age.?No information should be submitted nor posted to Autodesk websites or applications by children 12 years old or under.

Information and content that you disclose
Some of our websites and applications allow you to post "likes," comments, profile information (including profile images), videos, photographs, images, design files, and other content for others to see.?In some cases you can limit who can view or access information and content you post.?In other cases, the information and content might be available to registered members of the application or website, or even to the general public.

We urge you to be careful and thoughtful when deciding to disclose personal information, or any other information, on our applications and websites.?If you are posting information you to not want to be disclosed publicly, make sure you are using a website or application that allows you to control who sees information you have posted.

Please note that in some of our application and website forums, your name, user name, profile image, or email address may be posted along with any message you post.?For example, information posted on Area, Instructables and Socialcam will be public by default.?If you choose to share personal information in this way, the access limitations, security protocols and other commitments in this privacy statement will not apply to the information shared.

For some websites or applications, we may allow access to certain content that you have shared publicly, including personal information, through an application programming interface (API).?Learn more. Storage, retention and deletion of personal information
We store personal information and data files associated with you on Autodesk servers and servers of companies we hire to provide services to us.?This information may be stored in the United States and in other countries where Autodesk operates, and in countries where our service providers who help us run our business operate.? Please see the?sharing with third parties?section for more information about our practices and requirements we place on service providers.

If you are in the European Union, Switzerland, or other regions with laws governing data collection and use, you agree to the transfer to, and processing and storage of your personal information in the United States and other countries, the privacy laws of which may be considered as being less strict than those of your region.?This consent applies in addition to other legal grounds for transfer, processing and storage of your personal information, such as for contract fulfillment purposes.

We will keep personal information about you only as long as we need it:

• to honor your choices,
• to fulfill the purposes described in this privacy statement, or
• as required or permitted by applicable laws and regulations

For example, some laws and regulations may require us to retain certain transactional data.?We take reasonable measures to destroy or permanently de-identify personal information in a secure manner when it is no longer required.?For example, when the information is printed on paper, we take reasonable measures to delete or destroy it by shredding or incineration; where the information is stored electronically, we use technical means to render the information unusable.

How we use information
We use information about you in a number of ways, including:

• Providing you with access to our websites and applications for which you are eligible.
• Providing you with services, support or information you have requested.
• Sending you business communications.?Examples include sending you application service packs, notices about upcoming events like an account or subscription expiration date, or reminders that you need to take an action such as complete a payment.
• Sending you communications with information about us, including about new applications and special offers or promotions.?Sometimes a company or organization (including ones with which we have a business relationship) may ask us to make a business introduction to one or more users of 123dapp.com, Socialcam, Instructables, Pixlr and similar websites and applications, and we may contact you with details and to ask if you are interested.?Learn more about your choices.
• Measuring and better understanding how our websites and applications are used, so we can improve them.
• Tailoring your overall experience with us, our websites, applications, as well as our marketing.
• Reducing software piracy, fraud, ensuring our applications and websites are used in compliance with applicable terms and the law, and protecting our customers and end users.
• Sending questionnaires and surveys in order to provide better applications and experiences to our customers and end users. Your completion of any questionnaire or survey is voluntary.
• As explained in any supplemental privacy or data collection notice for a website or application.
• Sharing within our family of companies?and?sharing information with third parties?as described below.
• For any related purpose that you would reasonably expect, such as general administrative functions.

Sharing information inside the Autodesk family of companies
We may share your personal information within Autodesk or any of?our subsidiary companies worldwide?for purposes of

• data processing or storage
• providing you with access to our websites and applications
• guiding decisions about websites, applications, and communications
• for other purposes described in this privacy statement

Autodesk, Inc. is the party responsible for the management of the jointly-used personal information, and we and our subsidiaries agree to follow principles and procedures that help protect your personal information.

Sharing information with third parties
We may share information about you with companies, contractors and agents that help us to run our business.?These companies, contractors and agents provide services to us like fulfilling orders, sending emails to you on our behalf, delivering customer support, and processing payments.?They will have access to some of your information, limited to what they need to have to provide services.? We require these companies, contractors and agents to agree to use reasonable safeguards to protect information about you.?They are not allowed to use the information collected by us for their own purposes.

We may also share information about you:

• When you agree to the sharing.?We do not share personal information about consumers with third parties for their own direct marketing purposes unless the consumer agreed to that sharing.?Under certain programs, we may offer to make an introduction between a consumer and another company.?Learn more.
• If you are a business customer, with our channel partners and sales partners for operational purposes, such as order fulfillment and to confirm information about what applications you have access to.
• When the company, organization or institution through which you have access to our websites and applications has set up an agreement with us to receive user-specific information, subject to privacy laws.
• When we are required provide information to comply with applicable laws, subpoenas, court orders or other legal processes.
• When we have a good faith belief that the disclosure is necessary to prevent or respond to fraud, defend our websites or applications against attacks, or protect the rights, property and safety of Autodesk, our customers and users, or the public.
• If we merge with another company or if we decide to sell or reorganize some part or all of our business, assets or stock (including if we file for bankruptcy or are part of a similar proceeding).?You acknowledge that such transfers may occur, and that any acquirer of the part of our business, assets or stock affected may continue to use information about you as set forth in this privacy statement.
• We may share or publish aggregated information and other information that does not specifically identify you, such as statistics about the number of visitors to our websites or about how customers and end users use our applications.

Security and integrity of personal information
We use a combination of administrative, technical and physical security controls to help protect your personal information from unauthorized access, use, or disclosure.?However, despite our efforts, no security controls are 100% effective, and we cannot completely ensure or warrant the security of your personal information.

Information access, controls and choices

Profile informationWe want to be sure the personal information we maintain is accurate, complete and up to date.?You may have the right under applicable data protection laws to access the personal information that we keep for you, on request to us, except in certain limited circumstances (for example, where an applicable law requires us to deny such access).

You can update, correct or delete your profile information by following the instructions below.?Also, note that we need to retain certain records for legal or internal business reasons, and some of your information may remain on backup systems, in compliance with applicable law.

• Autodesk ID.?Login and make edits to your profile and information by following the instructions.?A?sign in help page?is available if you have any problems.? Users from Japan with a Contact ID, please use the?Japan login page.
• Socialcam, Instructables and Pixlr.?Login to the applicable website or application and make changes to your profile and information by following the instructions.
• For help with these or other websites or applications, please?contact us. Please tell us the specific website or application you need help with, along with your specific request.?Please note that if you contact us to assist you, for your safety and ours we may need to authenticate your identity before fulfilling your request.

Removing content you have postedTo remove content you have shared on our websites and applications, please use the same website or application feature you used to share the content and follow the instructions.?An option to remove content may not always be available, for example on forums.

Where someone has invited you to comment on, or view or edit content through our websites or applications, you may be able to edit or delete your contributions or the user who has invited your participation may have control over these options.

Marketing choices

• Autodesk?- You can subscribe to or unsubscribe from Autodesk marketing communications, using our?webform, or follow the unsubscribe instructions in communications you receive.
• Instructables???Login?to your account at the Instructables website and change your marketing preferences, or follow the unsubscribe instructions in communications you receive.
• For other communications follow the unsubscribe instructions in the communications you receive, or if you need help please?contact us.

Remember, we may need to contact you for business reasons and you cannot unsubscribe or opt-out from these communications.

Introduction programsSometimes companies or organizations, including ones with whom we have business relationships, will ask us to make an introduction to one or more members of 123dapp.com, Socialcam, Instructables, Pixlr and similar websites and applications.?We may contact you with details and to see if you are interested in the introduction.?You can say no to a specific introduction, and you can also ask not to receive requests for introductions in the future.

Application programming interfacesWe may allow access to certain content, including personal information, posted through websites or applications through an application programming interface (API).

API access will be mentioned in the applicable terms of service.?We place limitations?on what third party developers can do with information.?Below is information about your choices.

Public information access by third-party applications

On some websites and applications, content you post is public and cannot be marked as non-public or private.?Check the posting controls for the specific application or website you are using.

Where there is an option to mark content as private or otherwise choose a non-public status, and you choose the non-public option, third party developers will not be able to access the following information through a public information access API:

• the content (including its title, and public comments you include with the content);
• the name (or pseudonym) associated with your account;
• the profile image associated with you;
• the profile URL (which may include user ID) for the account.

If your content is "public" but you do not want developers to have access to your real name or profile image (for example, if it is a picture of your face), use a pseudonym or "handle" and use a profile image that does not consist of a picture of you.

Authenticated access by applications

You may choose to use third party applications that manage your interactions with our websites or applications.?For example, third party applications may want to do the following types of activities:

• Manage relationships: to manage user relationships on your behalf, such as follow, unfollow, block, and unblock people, and to approve people who want to follow you on our website or application;
• Manage content: to post and remove content on your behalf;
• Manage likes: to manage likes and similar actions on your behalf; and
• Manage comments: to manage and post comments on your behalf.

We require the app developers to explain what actions they will take and also what information (including personal information) they need to access in order to take these actions, and to get your approval.?In addition, we require developers to provide a link to an explanation of their privacy practices.

It is your choice to approve or not approve access by these third party applications.

Limitations on access by third party applications

In both cases described above, third party application developers are not allowed to use your personal information for marketing or promotional purposes without your consent, and are otherwise restricted in their use of your information by the terms of the applicable App Developer Agreement.

You can find links to the applicable App Developer Agreement through the applicable terms of service.?For convenient reference, here is a non-exclusive list of the current agreements:

Cookies and similar technologiesAutodesk and our service providers may use "cookies," "pixel tags," "web beacons," "clear GIFs," or other similar technologies in connection with website pages and HTML-formatted e-mail messages to, among other things, track the actions of website users and e-mail recipients, determine the success of marketing campaigns, compile aggregate statistics about website usage and response rates and make it easier for you to navigate our website or better tailor your experience with us, for example by not requiring you to submit login credentials repeatedly or by showing you content targeted to your interests.?

A "cookie" is a commonly used automated data collection tool.? A cookie is a small amount of data that is sent to a browser from a web server and gets saved on the hard drive of the computer that you are using. ?Cookies and similar tools collect standard information from your browser such as browser type, browser language, and the website address you came from when you visited our website. They may also collect information about your Internet Protocol (IP) address, and clickstream behavior (for example, the pages you view and the links you click), along with the date and time of your visit or request, and one or more cookies that may uniquely identify your browser or your account.?

If you do not want information collected through the use of cookies, there is a simple procedure in most browsers that allows you to automatically decline cookies, or to be given the choice of declining or accepting the transfer of a particular cookie, or cookies from a particular web site, to your computer.

If you set your browser to reject all cookies, you will be unable to use our websites and applications that require registration or customization in order to participate. If you choose to accept cookies from us and our service providers, you are granting us and our service providers your consent to set cookies on your computer. To learn more about cookies and other automatic data collection tools, please visit?www.allaboutcookies.org. When we send you emails, they might include a web beacon or similar technology that lets us know if you received or opened the email and whether you clicked on any of the links in the email.?You can?opt-out of marketing emails. Advertising, including mobile adsSome of our mobile applications and websites may contain ads.?Learn moreabout advertisements.

For more information about a specific mobile application, please see the About section (iOS devices) or the Legal/Privacy section (Android devices).?

You may opt out of the use of your information by Ad Partners by using theNetwork Advertising Initiative tool.? If you delete all cookies, use a different browser, or use a different computer, you will need to use the tool to renew your opt out choice.

In-application usage metrics and analytics

• Customer Involvement Program (the CIP)?? For our commercial products that include the option to participate in the CIP, you will be prompted about participating.?You can change your choice by going to the Help menu, opening the CIP dialogue box, and following the instructions.?Your choice will apply to all commercial Autodesk products installed on your computer.?Learn more about the CIP.
• Trial, preview and pre-release (beta) applications?? For trial, preview or beta applications your limited or full participation in an in-application analytics program may be a condition of receiving access to those products.?Please review the applicable terms of service, license agreement and any specific privacy or data collection notice attached to a given application for more details.?If you do not wish to participate please do not use these products.
• Customer Error Reporting and similar programs?? You will be asked if you want to send in error reports, wither through our Customer Error Reporting program or an application specific error reporting program.?In each case, a dialog box will appear in-application, and you will be told what information the tool will collect, how it will be sent to us, and any other relevant information about the tool or its use.?You must choose to send us the report.?Learn more about CER.
• Mobile applications?? We may use third party analytics services to support analytics for some of our mobile applications.?For details about a specific mobile application, please read the About section (iOS devices) or the Legal/Privacy section (Android devices).?You can opt-out of data collection for an application by following the in-application instructions.?Unless the data collection notice in About or Legal/Privacy tells you otherwise, the control selection will be located in the application or device settings (iOS devices) or the settings menu (Android devices).

For convenience, here is a non-exclusive set of links to the privacy policies and opt-out instructions to services we may use:

Contacting our ecommerce providers

• For the Autodesk Online Store, contact Digital River as set forth in theirprivacy policy.
• For 123D and related applications, contact Turbo Squid as set forth in their?privacy policy.

Customer controlled servicesAutodesk customers may invite you to participate in a customer-specific site of an application, such as the Autodesk PLM360, Buzzsaw, or Constructware services.?The customer site administrator manages these invitations, and requests to change or update information you provided when registering should be directed to that site administrator.?AUTODESK ACTS ONLY AS A SERVICE PROVIDER TO OUR CUSTOMERS IN CONNECTION TO THESE APPLICATIONS, AND IS NOT RESPONSIBLE OR LIABLE FOR THE USE AND/OR DISCLOSURE OF PERSONAL INFORMATION ABOUT YOU BY SUCH CUSTOMERS.

Changes to this privacy statement
We may update this privacy statement from time to time.?Check the "last updated" section at the top of this privacy statement to see the last time the privacy statement was changed.

If we decide to make changes to our privacy statement on a forward going basis, we will tell you and other users by placing a notice onwww.autodesk.com?and/or by sending you a notice to the e-mail address (if any) we have on file for you. We may also give you notice through our applications and on our other websites. You should periodically checkwww.autodesk.com, our other websites and this Privacy Statement for updates.?Your continued use of our applications and websites constitutes your agreement to this privacy statement. For changes to this privacy statement that may be materially less restrictive on our use or disclosure of personal information you have provided to us, we will obtain your consent before implementing the change.? Pleasecontact us?if you have questions.

Source: http://bimboom.blogspot.com/2013/05/autodesk-legal-notices-trademarks.html

milwaukee bucks bear grylls us news law school rankings gael glen rice jr bars lindzi cox

Carlesimo out as Nets coach after playoff ouster

FILE - In an April 22, 2013, file photo Brooklyn Nets interim head coach P.J. Carlesimo reacts in the second half of Game 2 of a first-round NBA basketball playoff series against the Chicago Bulls in New York. Brooklyn Nets general manager Billy King says P.J. Carlesimo will not return as coach. (AP Photo/Kathy Willens)

FILE - In an April 22, 2013, file photo Brooklyn Nets interim head coach P.J. Carlesimo reacts in the second half of Game 2 of a first-round NBA basketball playoff series against the Chicago Bulls in New York. Brooklyn Nets general manager Billy King says P.J. Carlesimo will not return as coach. (AP Photo/Kathy Willens)

NEW YORK (AP) ? After spending $350 million to upgrade their roster last summer, the Brooklyn Nets will start this offseason by looking for a coach.

The Nets announced Sunday that P.J. Carlesimo wouldn't return, hours after they were eliminated in the first round of the playoffs.

Carlesimo helped the Nets finish 49-33 after replacing the fired Avery Johnson in December, earning the No. 4 seed in the Eastern Conference.

But they spotted the Chicago Bulls a 17-point halftime lead and lost 99-93 at home Saturday night in Game 7.

"The Brooklyn Nets organization would like to thank P.J. for his efforts with the team in his roles as both head coach and assistant, and for his contributions to the team's success both on and off the court. We wish P.J. and his family only the best in the years to come," general manager Billy King said in a statement.

King received a recent contract extension, but the Nets quickly decided they wanted someone new on the bench, even after Carlesimo went 35-19 on an interim basis.

The Nets were one of the NBA's busiest teams last summer. They re-signed starters Deron Williams, Brook Lopez and Gerald Wallace and traded for Atlanta Hawks All-Star Joe Johnson in hopes of being a contender in their first season in Brooklyn after they were longtime losers in New Jersey.

They got back to the playoffs for the first time since 2007, but expectations were higher, with owner Mikhail Prokhorov saying in the preseason that he thought the Nets could make the conference finals.

"In one sense, I will say how far we've come from last year, infinitely. But we didn't get as far as we wanted to get," Carlesimo said Saturday night.

"I think we made enormous progress from where we were last year and what these guys accomplished this year, but to me it's a hill. You're always trying to climb up the hill. You go up; you go back. But we thought we could get higher up the hill than we got."

The Nets were just 14-14 after a December slump, prompting Prokhorov, their billionaire Russian owner, to cut short a winter vacation and fire Johnson.

The Nets won 12 of their first 14 under Carlesimo and went 10-3 down the stretch to earn home-court advantage in the first round. They fell behind 3-1 against Chicago, and their comeback came up short Saturday as they tried to become the ninth NBA team to overcome that deficit and win a series.

Phil Jackson was the Nets' priority after firing Johnson, and they may try to make a run at him now.

It was clear the Nets, despite boosting their talent on the roster, need to fill it with more passion. Given the money they have committed to the current group, it will be difficult to change the players, so they may want a coach who can bring that out of them.

They couldn't match the effort of the Bulls, who played harder to make up for the absences of starters Luol Deng and Kirk Hinrich during the series.

"I think we have a great group of the guys in the locker room. I just think, like I said, we talked about the word inconsistency all year. I think we just need to find a way to be more consistent, especially mentally," Williams said after the game. "I think that's what got us this series, is just the toughness, the mental breakdowns."

Carlesimo has a career record of 239-315, also serving as a head coach with Portland, Golden State and Seattle/Oklahoma City.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-05-05-BKN-Nets-Carlesimo/id-b67489073d0a438680d5415071397759

Amanda Todd washington nationals Gary Collins bus driver uppercut Alex Karras BCS Rankings 2012 vampire diaries

Kentucky Derby Betting: Will The New Qualification Format Impact ...

That?s the question that many horse racing experts are asking heading into the 2013 Kentucky Derby. Granted, most recreational horse players aren?t even aware that the qualification process for the Kentucky Derby has been altered but even they should understand at least the basic concepts of the changes if they?re looking to bet the race. The impact of the new qualification system is still being debate and probably won?t be fully determined until there?s a few races run under the new format. Since that won?t do you much good in terms of betting this year?s race we?ll summarize the changes and the arguments over how it?ll impact the race.

In the past the Kentucky Derby had a fairly wide open qualification process. A trainer showed up and paid the entry fee and his horse could run. Well, it?s not quite that simple?the horse could run provided that the field wasn?t ?oversubscribed? meaning if there wasn?t more horses than could be accommodated by the 20 entry limit in the Derby. At that point, eligible horses were ranked by the money they?d earned in graded stakes events. Not surprisingly, in recent years there has almost always been more than 20 horses looking to get into the field and connections were very cognizant of their chances of qualifying based on graded stakes earnings so if they weren?t ?in the hunt? they wouldn?t even bother.

For the first time this year there?s a more regimented process for qualifying for the Kentucky Derby via a NASCAR-esque ?points system? where horses earn points in designated prep races. In many ways this is a different way of achieving the same result but it does have it?s upsides, not the least of which is a stronger field and more urgency in many of the bigger prep events. There are some consequences?for example, under the new format the chances of a top flight filly like Rachel Alexandra or Zenyatta qualifying are slim and none. Some suggest this is a good thing.

But how will the new format impact the race itself? Noted handicapper Andy Beyer and others suggest that it will create a slower pace than in years past. Beyer?s theory is long on speculation and short on empirical examples but does make some sense?under the new format their are fewer sprinters looking to set insane fractions and more closers. Without insane front running speed a more manageable pace will materialize and make strong closing horses an event better bet.

Like just about everything else in horse racing there are proponents as well as detractors from this theory. Some suggest that Beyer?s ?insane sprinters? scenario is more fiction than fact and just hasn?t been borne out by the data of actual races. In any case, if you?re going to bet the Kentucky Derby you should be aware that the nature of the race may have changed due to the changes in the qualification process.

Source: http://maboot.com/will-the-new-qualification-format-impact-kentucky-derby-betting/

carson daly heejun han donovan mcnabb donovan mcnabb lottery ticket megga millions what is autism

Texas plant that blew up carried $1M policy

FILE - This April 18, 2013 file photo shows mangled debris of a West Fertilizer Company's fertilizer plant a day after an explosion leveled the plant in West, Texas. Burglars occasionally sneaked into the plant in the years before its deadly explosion last month ? sometimes looking for a chemical fertilizer that can be used to make methamphetamine, according to local law enforcement records. (AP Photo/Charlie Riedel, File)

FILE - This April 18, 2013 file photo shows mangled debris of a West Fertilizer Company's fertilizer plant a day after an explosion leveled the plant in West, Texas. Burglars occasionally sneaked into the plant in the years before its deadly explosion last month ? sometimes looking for a chemical fertilizer that can be used to make methamphetamine, according to local law enforcement records. (AP Photo/Charlie Riedel, File)

File - In this April 17, 2013, file photo provided by Joe Berti, a plume of smoke rises after an explosion at West Fertilizer Company's fertilizer plant in West, Texas. Burglars occasionally sneaked into the plant in the years before its deadly explosion last month ? sometimes looking for a chemical fertilizer that can be used to make methamphetamine, according to local law enforcement records. (AP Photo/Joe Berti, File)

Texas A&M University freshman Heather Warfield collects baseball cards from a nearby apartment complex, Saturday, May 4, 2013, in West Texas. Over 124 students donated their time to help cleanup parts of West devastated by the fertilizer plant explosion. The plant exploded during a fire April 17, killing at least 14 people and injuring about 200. (AP Photo/Waco Tribune Herald, Rod Aydelotte)

Texas A&M students clean debris at a home in West, Texas, Saturday, May 4, 2013, that was damaged due to the explosion at a fertilizer plant in West on April 17. The plant that exploded, killing 14 people, injuring more than 200 others and causing tens of millions of dollars in damage to the surrounding area, had only $1 million in liability coverage, lawyers said Saturday. (AP Photo/Waco Tribune Herald, Rod Aydelotte)

Texas A&M students walk past an apartment complex in West, Texas, Saturday, May 4, 2013, that was damaged due to the explosion at a fertilizer plant on April 17. The plant that exploded, killing 14 people, injuring more than 200 others and causing tens of millions of dollars in damage to the surrounding area, had only $1 million in liability coverage, lawyers said Saturday. (AP Photo/Waco Tribune Herald, Rod Aydelotte)

McALLEN, Texas (AP) ? The Texas fertilizer plant that exploded last month, killing 14 people, injuring more than 200 others and causing tens of millions of dollars in damage to the surrounding area had only $1 million in liability coverage, lawyers said Saturday.

Tyler lawyer Randy C. Roberts said he and other attorneys who have filed lawsuits against West Fertilizer's owners were told Thursday that the plant carried only $1 million in liability insurance. Brook Laskey, an attorney hired by the plant's insurer to represent West Fertilizer Co., confirmed the amount Saturday in an email to The Associated Press, after the Dallas Morning News first reported it.

"The bottom line is, this lack of insurance coverage is just consistent with the overall lack of responsibility we've seen from the fertilizer plant, starting from the fact that from day one they have yet to acknowledge responsibility," Roberts said.

Roberts said he expects the plant's owner to ask a judge to divide the $1 million in insurance money among the plaintiffs, several of whom he represents, and then file for bankruptcy.

He said he wasn't surprised that the plant was carrying such a small policy.

"It's rare for Texas to require insurance for any kind of hazardous activity," he said. "We have very little oversight of hazardous activities and even less regulation."

On April 17, a fire at the West Fertilizer Co. in West, a town 70 miles south of Dallas, was quickly followed by an earth-shaking explosion that left a 90-foot wide crater and damaged homes, schools and nursing home within a 37-block blast zone. Among those killed were 10 emergency responders.

State and federal investigators haven't determined what caused the blast.

The plant had reported just months before the blast that it had the capacity to store 270 tons of ammonium nitrate, but it was unknown how much was there at the time of the explosion.

Roberts said that even without a conclusive cause, negligence lawsuits can proceed.

"The law allows courts to presume negligence when something happens that would not ordinarily occur but for negligence," Roberts said. "A fire might be an unavoidable accident, but a fire of this magnitude resulting from a fire is not an unavoidable accident."

Lawyers will look for any other assets the company might have and search for other responsible parties, he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-05-04-Plant%20Explosion-Insurance/id-3a4fe25b513c43d4a44bdc29586e81bf

hanley ramirez Christian Bale visits victims Christian Bale Sherman Hemsley Olympics Opening Ceremony Katherine Jackson Olympics Opening Ceremony Time

Collector keeps his 29 boa constrictors _ for now

Thomas Cobb lets his young son Daiden hold one of his snakes as he shows off several of his exotic reptile that he keeps in a special basement room of his home, Friday, April 26, 2013 in Cottonwood Heights, Utah. Cobb has been ordered by police to get rid of all but one of his 29 exotic boa constrictor snakes because he doesn?t have an exotic pet permit. (AP Photo/The Deseret News, Scott G. Winterton) SALT LAKE TRIBUNE OUT; MAGS OUT

Thomas Cobb lets his young son Daiden hold one of his snakes as he shows off several of his exotic reptile that he keeps in a special basement room of his home, Friday, April 26, 2013 in Cottonwood Heights, Utah. Cobb has been ordered by police to get rid of all but one of his 29 exotic boa constrictor snakes because he doesn?t have an exotic pet permit. (AP Photo/The Deseret News, Scott G. Winterton) SALT LAKE TRIBUNE OUT; MAGS OUT

Caiden Cobb admires one of his father's snakes, Friday, April 26, 2013 in Cottonwood Heights, Utah. Thomas Cobb has been ordered by police to get rid of all but one of his 29 exotic boa constrictor snakes because he doesn?t have an exotic pet permit. (AP Photo/The Deseret News, Scott G. Winterton) SALT LAKE TRIBUNE OUT; MAGS OUT

Thomas Cobb shows off several of his exotic reptiles that he keeps in a special basement room of his home Friday, April 26, 2013 in Cottonwood Heights, Utah. Cobb has been ordered by police to get rid of all but one of his 29 exotic boa constrictor snakes because he doesn?t have an exotic pet permit. (AP Photo/The Deseret News, Scott G. Winterton) SALT LAKE TRIBUNE OUT; MAGS OUT

Thomas Cobb shows off several of his exotic reptiles that he keeps in a special basement room of his home, Friday, April 26, 2013 in Cottonwood Heights, Utah. Cobb has been ordered by police to get rid of all but one of his 29 exotic boa constrictor snakes because he doesn?t have an exotic pet permit. (AP Photo/The Deseret News, Scott G. Winterton) SALT LAKE TRIBUNE OUT; MAGS OUT

Thomas Cobb shows off several of his exotic reptiles that he keeps in a special basement room of his home Friday, April 26, 2013 in Cottonwood Heights, Utah. Cobb has been ordered by police to get rid of all but one of his 29 exotic boa constrictor snakes because he doesn?t have an exotic pet permit. (AP Photo/The Deseret News, Scott G. Winterton) SALT LAKE TRIBUNE OUT; MAGS OUT

SALT LAKE CITY (AP) ? A Utah snake collector who says his rare boa constrictors are getting a bad rap has won at least a temporary reprieve from an order to remove more than two dozen of the exotic pets from his home.

Cottonwood Heights police cited Thomas Cobb a week ago for failure to have an exotic pet permit and told him he had until Friday to get rid of all but one of his 29 boa constrictors.

Cobb values the snakes at $12,000 apiece and said he spent $100,000 on a special room in his basement with top-of-the-line cages. Some of the snakes are as long as 7 feet. Police officers noted in their report the setup was clean and well-kept.

City council members agreed on Friday to look into the case further after Cobb argued that a local ordinance is confusing.

Cobb got the attention of the council and the mayor after he took his fight against the snake eviction to the Internet and local radio shows. He maintains he's the victim, in part, of the public's distaste for snakes in general.

"We see movies, we see 'Snakes on a Plane,' we see 'Anaconda,' we see these movies where snakes are portrayed as monsters and can eat school buses, and that is not the case," he told The Deseret News (http://tinyurl.com/cajkcvn).

Cobb praised the council for having an open mind.

"I am pleased to find that they are at least willing to take and investigate further rather than make assumptions and going off on maybe their personal belief on snakes and maybe the reptile hobby keeping in general," he said.

Cottonwood Heights police Sgt. Dan Bartlett said a neighbor spotted one of the snakes and called police to Cobb's home last week. He said officers also found 80 rats, which were being kept as food for the snakes.

Cobb was cited for failing to have the permit required when anyone owns more than one exotic pet. He disputes that interpretation and maintains he needs to show only that he can properly care for the snakes, that they do not pose a danger to the public and that he has knowledge of the animals.

Cobb is scheduled to meet again with the council on May 7. He said he has invited all of the council members to his house to see the snakes firsthand, but as of Friday no one had taken him up on the offer.

___

Information from: Deseret News, http://www.deseretnews.com

Source: http://hosted2.ap.org/APDEFAULT/aa9398e6757a46fa93ed5dea7bd3729e/Article_2013-05-04-Exotic%20Snake%20Collector-Reprieve/id-201d59ce4ddd4bc18cf9a447a0182668

nike nfl jerseys katie couric barista university of kentucky oakland news alec baldwin alec baldwin

Around the Web?

TGIF! Get your weekend started right with these reads: Molly Sims‘ message to moms: Get rid of the sweat pants — Pr?t ? Pregnant The number of single women giving birth has skyrocketed — HuffPost Women Architects design a home — and then take on the child’s playhouse — Apartment Therapy 8 ways to celebrate [...]

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/_qkrCcf56ME/

ufc 144 fight card ufc 144 results acura nsx all star weekend 2012 giada de laurentiis howard hughes nationwide race

Researchers find active transporters are universally leaky

Public release date: 2-May-2013
[ | E-mail | Share ]

Contact: William Gillespie
gillespi@life.illinois.edu
217-265-0927
School of Molecular and Cellular Biology, University of Illinois, Urbana

Professor of Biochemistry Emad Tajkhorshid and colleagues have discovered that membrane transporters help not just sugars and other specific substrates cross from one side of a cellular membrane to the otherwater also comes along for the ride.

There are two main ways that molecules can cross a membrane. In passive transport, molecules are able to pass through a membrane protein called a channel (which provides a wide open pathway) to get from the high concentration side to low concentration side of the membrane. This requires no energy as the molecule flows easily down its concentration gradient. In active transport, molecules are pumped by a membrane protein called an active transporter to get from the low concentration side to the high concentration side. This process requires energy, because the molecule must be pumped across the membrane against its natural concentration gradient.

In order to do their job, active transporters use the alternative access mechanism. At first, only one side of the transporter protein is open, allowing only substrate molecules on that side of the membrane to bind to the transporter. Then, a change in the transporter's shape occurs so that first the open side closes, and then the other side of the transporter protein opens, successfully moving the substrate molecule to its destination.

The surprise is that this perfect coordination works only for the main substrate of active transporters, while small molecules such as water seem to be able to sneak through while the protein is undergoing its shape change. The research conducted by the Tajkhorshid group suggests that this is likely a universal behavior for all active membrane transporters and a result of the very large structural changes they undergo.

Researchers study membrane proteins using a tool called molecular dynamics. "All the molecules in biology have to move to do their job. While you can see a lot of nice pictures of proteins showing their structure, but that's just a frozen state," Tajkhorshid said. "In order to describe the function of a biomolecule, you have to see its motion, and molecular dynamics is a nice way to do this. The method essentially solves the Newtonian equations of motion for all the atoms in the molecule we like to study."

The computer simulations involved in molecular dynamics determine the motion of the transporters using algorithms that define how the atoms of a transporter interact with each other, how they interact with solvent, and how they interact with other molecules in the system. These rules are used to calculate the total force acting on every atom at each step of the transporter's motion.

However, challenges arise when doing these computer simulations because of the sheer number of atoms and the small time steps these simulations require.

"Atoms vibrate of a period of 10 femtoseconds [one quadrillionth of a second], so if you want to have ten snapshots nicely showing how it moves, you have to take a picture every one femtosecond to describe the natural motion of the system. Because we have to take such short time steps, calculating even a few microseconds of protein motion becomes computationally very expensive. Thanks to the power provided by the national supercomputing centers we have been able to accomplish such calculations." Tajkhorshid said.

Once these molecular dynamics simulations were up and running, members of Tajkhorshid's lab noticed something that they never expected to see: the transporters were leaking, allowing small amounts of water to pass through along with the substrate.

"Initially, I was surprised, because many people, including myself, assumed that these were perfect machines going back and forth between inward facing and outward facing states," Tajkhorshid said. "For almost two years, my students told me that there was some water passing through, and I just told them to repeat their simulations using more carefully designed setups, and that something was probably wrong with their simulations!"

With a little digging, the researchers found that some other labs had experimentally shown that some transporters did, in fact, have this leaky quality.

"What we did in this work was to propose that it's not just one particular family that has this leakiness, but all of the transporters that we have been studying in the lab. We found that in all cases, every time the protein starts to undergo those large structural changes, leaks form," Tajkhorshid said.

Tajkhorshid likens this mechanism to a scenario familiar to most pet owners.

"When you open the door for someone to come in, the door has to completely open, but that provides access to small things like a dog or a cat to get out of the house. Because transporters move so much when allowing a substrate in, these leaks form, allowing water molecules in," Tajkhorshid said.

Although Tajkhorshid doesn't believe transporter leakiness plays a physiological role in the cell, this discovery adds some interesting new knowledge to the field about transporters.

"Transporters are extremely important proteins, and we would love to understand their function and how they move. If we understand that better, then we might be able to design better, more specific drugs for transporters," Tajkhorshid said.

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 2-May-2013
[ | E-mail | Share ]

Contact: William Gillespie
gillespi@life.illinois.edu
217-265-0927
School of Molecular and Cellular Biology, University of Illinois, Urbana

Professor of Biochemistry Emad Tajkhorshid and colleagues have discovered that membrane transporters help not just sugars and other specific substrates cross from one side of a cellular membrane to the otherwater also comes along for the ride.

There are two main ways that molecules can cross a membrane. In passive transport, molecules are able to pass through a membrane protein called a channel (which provides a wide open pathway) to get from the high concentration side to low concentration side of the membrane. This requires no energy as the molecule flows easily down its concentration gradient. In active transport, molecules are pumped by a membrane protein called an active transporter to get from the low concentration side to the high concentration side. This process requires energy, because the molecule must be pumped across the membrane against its natural concentration gradient.

In order to do their job, active transporters use the alternative access mechanism. At first, only one side of the transporter protein is open, allowing only substrate molecules on that side of the membrane to bind to the transporter. Then, a change in the transporter's shape occurs so that first the open side closes, and then the other side of the transporter protein opens, successfully moving the substrate molecule to its destination.

The surprise is that this perfect coordination works only for the main substrate of active transporters, while small molecules such as water seem to be able to sneak through while the protein is undergoing its shape change. The research conducted by the Tajkhorshid group suggests that this is likely a universal behavior for all active membrane transporters and a result of the very large structural changes they undergo.

Researchers study membrane proteins using a tool called molecular dynamics. "All the molecules in biology have to move to do their job. While you can see a lot of nice pictures of proteins showing their structure, but that's just a frozen state," Tajkhorshid said. "In order to describe the function of a biomolecule, you have to see its motion, and molecular dynamics is a nice way to do this. The method essentially solves the Newtonian equations of motion for all the atoms in the molecule we like to study."

The computer simulations involved in molecular dynamics determine the motion of the transporters using algorithms that define how the atoms of a transporter interact with each other, how they interact with solvent, and how they interact with other molecules in the system. These rules are used to calculate the total force acting on every atom at each step of the transporter's motion.

However, challenges arise when doing these computer simulations because of the sheer number of atoms and the small time steps these simulations require.

"Atoms vibrate of a period of 10 femtoseconds [one quadrillionth of a second], so if you want to have ten snapshots nicely showing how it moves, you have to take a picture every one femtosecond to describe the natural motion of the system. Because we have to take such short time steps, calculating even a few microseconds of protein motion becomes computationally very expensive. Thanks to the power provided by the national supercomputing centers we have been able to accomplish such calculations." Tajkhorshid said.

Once these molecular dynamics simulations were up and running, members of Tajkhorshid's lab noticed something that they never expected to see: the transporters were leaking, allowing small amounts of water to pass through along with the substrate.

"Initially, I was surprised, because many people, including myself, assumed that these were perfect machines going back and forth between inward facing and outward facing states," Tajkhorshid said. "For almost two years, my students told me that there was some water passing through, and I just told them to repeat their simulations using more carefully designed setups, and that something was probably wrong with their simulations!"

With a little digging, the researchers found that some other labs had experimentally shown that some transporters did, in fact, have this leaky quality.

"What we did in this work was to propose that it's not just one particular family that has this leakiness, but all of the transporters that we have been studying in the lab. We found that in all cases, every time the protein starts to undergo those large structural changes, leaks form," Tajkhorshid said.

Tajkhorshid likens this mechanism to a scenario familiar to most pet owners.

"When you open the door for someone to come in, the door has to completely open, but that provides access to small things like a dog or a cat to get out of the house. Because transporters move so much when allowing a substrate in, these leaks form, allowing water molecules in," Tajkhorshid said.

Although Tajkhorshid doesn't believe transporter leakiness plays a physiological role in the cell, this discovery adds some interesting new knowledge to the field about transporters.

"Transporters are extremely important proteins, and we would love to understand their function and how they move. If we understand that better, then we might be able to design better, more specific drugs for transporters," Tajkhorshid said.

###

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-05/soma-rfa050213.php

green eggs and ham wiz khalifa and amber rose oh the places you ll go blunt amendment justin bieber birthday read across america vikings stadium